Erythropoiesis in Rats with Acute Uremia and the Effect of Erythropoietin.
نویسندگان
چکیده
By EFSTRATIOS S. KURTIDES, WALTER A. RAMBACH AND HOWARD L. ALT T HE INCORPORATION of tritiated thymidine by the rat spleen is an accurate and reliable index of erythropoiesis under certain well-defined experimental conditions.1 Since tritiated thymidine uptake by various tissues reflects DNA synthesis, and therefore proliferative activity, changes in the latter will be reflected by parallel changes in the thyrnidine uptake. In the current experiments, tritiated thymidine incorporation by spleen, bone marrow, intestine and thymus was studied in normal and acutely uremic rats. In addition, the effect of exogenous erythropoietin on uremic erythropoiesis was investigated in these animals.
منابع مشابه
Erythropoietic response to anemia or erythropoietin injection in uremic rats with or without functioning renal tissue.
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ورودعنوان ژورنال:
- Blood
دوره 25 شماره
صفحات -
تاریخ انتشار 1965